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This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. The clinical trial will take place in three Canadian centers, including the Cross Cancer Institute in Edmonton, and will enroll patients with advanced and previously treated lymphoma, breast, … The study has randomized more than 10,200 women with this type of breast cancer at 1,182 sites in the … This randomized phase III trial studies whether weight loss in overweight and obese women may prevent breast cancer from coming back (recurrence). When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body’s immune system. Hormone therapy using fulvestrant or exemestane may fight breast cancer by blocking the use of estrogen by the tumor cells or reducing the amount of estrogen made by the body. The clinical trial will take place in three Canadian centers, including the Cross Cancer Institute in Edmonton, and will enroll patients with advanced and previously treated lymphoma, breast, … Squamous cell carcinoma variants of the genitourinary (GU) system 19. Study will last 3 months, 20 … Due to the nature of this study design, some tumor cohorts may complete enrollment earlier than others. For more information on participating in a trial … Krag D, et al. A recent trial (Lancet 2006) confirms that Herceptin offers benefit with early stage breast cancer patients too. Small cell carcinoma of the ovary, hypercalcemic type 49. Odontogenic malignant tumors 22. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body's immune system. Women with ER positive breast cancer normally will receive endocrine therapy and some may receive chemotherapy to help prevent the cancer from coming back. Giving fulvestrant with or without palbociclib and avelumab may work better in treating patients with breast cancer. Gallbladder cancer 48. Drugs used in chemotherapy, such as vinorelbine tartrate, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. N Engl J Med. This trial; Search. … Pertuzumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Location: 848 locations, This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. NSABP trials were among the first to demonstrate that the oral hormonal therapy, tamoxifen, could reduce the risk of breast cancer recurrence and improve survival. Location: 20 locations, This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD / RD and regimen of XmAb20717, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb20717 in subjects with selected advanced solid tumors. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. ... Summary. Effect of Radiotherapy After Mastectomy and Axillary Surgery on 10-year Recurrence and 20-year Breast Cancer Mortality: Meta-analysis of Individual Patient Data from 8135 Women in 22 Randomized Trials. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. for the CLEOPATRA Study Group. It is not known whether patients with low risk breast cancer need to receive regional radiotherapy. Lancet. However, it is not yet known whether proton therapy is more effective than photon therapy in treating patients with non-metastatic breast cancer without causing heart damage. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03 / 30 / 2018) 14. Trials measured cancer severity in terms of clinical stage (0 to IV), 23, 24, 68, 69 number of involved lymph nodes (0, 1 to 3, or ≥4), 18, 20, 25, 26, 70 and tumor size (mm), 19, 21, 26 and these varied across trials. This is a preview of subscription content. Adenocarcinoma with variants of small intestine (closed to accrual 05 / 10 / 2018) 6. Dale Shepard, MD, PhD: So in terms of reaching out specifically to patients within breast cancer trials and breast cancer care, how big of a role does social media, patient support groups, how big of a role does that play in terms of patient awareness of a trial … Location: 1372 locations, This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. Use of molecular tools to identify patients with indolent breast cancers with ultralow risk over 2 decades. Principal Investigator: Radhika Rachamalla, MD. FAST-Forward Lay Summary of Main Trial Results, v1.0 07/05/2020 1 Clinical trial testing a 1-week course of curative breast radiotherapy against a standard 3-week schedule in early breast cancer The FAST-Forward Trial … Swain S et al. The Breast Cancer Locator study is a prospective, 1:1 randomized, controlled pivotal trial that will enroll 448 women with non-palpable invasive breast cancer or ductal carcinoma in situ (DCIS) … Over 10 million scientific documents at your fingertips. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer, Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1 / 2 / 3 (Trk A / B / C), ROS1, or ALK Gene Rearrangements (Fusions), I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer, A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors, Fulvestrant or Exemestane with or without Ribociclib in Patients with Recurrent, Unresectable, or Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer, Capecitabine in Treating Patients with Metastatic Breast Cancer or Advanced / Metastatic Gastrointestinal Cancers, U.S. Department of Health and Human Services. Lancet. 2013;31(19):2382–7. Tumor of unknown primary (Cancer of Unknown Primary; CuP) (closed to accrual 12 / 22 / 2017) 33. The vaccine was developed by researchers at the Cleveland Clinic in Ohio and works by training the … Breast Cancer Clinical Trials Death rates from breast cancer have reduced greatly in the last couple of decades, and that has been made possible in part thanks to the medical advances that resulted from clinical trials … Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Location: 15 locations, This randomized, phase II trial studies how well fulvestrant or exemestane with or without ribociclib works in treating patients with hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer that has progressed after treatment with an aromatase inhibitor or cyclin-dependent kinase 4 / 6 inhibitor (recurrent), cannot be removed by surgery (unresectable), or has spread to other parts of the body (metastatic). All trials on the list are supported by NCI. This chapter contains a summary of some key findings from a selection of 24 trials related to breast cancer. pp 7-40 | The reason for this study is to see if the study drug LY3484356 alone or in combination with other anticancer therapies is safe and effective in participants with advanced or metastatic breast cancer or endometrial cancer. Radiation therapy is an important treatment for breast cancer, however, radiation goes to other organs, such as heart, causing heart problems. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. The IES trial was designed as an international, multicenter, randomized, double‐blind trial to compare the efficacy and safety of continued adjuvant tamoxifen therapy with exemestane therapy in postmenopausal women with primary breast cancer … Radiation therapy uses high-energy x rays or protons to kill tumor cells. Over the past 40 years, breast cancer treatment has greatly improved due to lessons learned through clinical trials. Location: 21 locations, The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success. At the moment they recommend that women at high or moderate risk of breast cance… Location: 15 locations, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Weight Loss Interventions in Treating Overweight and Obese Women with a Higher Risk for Breast Cancer Recurrence, Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial), Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel with or without Carboplatin in Treating Patients with Triple-Negative Breast Cancer, Lymph Node Dissection and Radiation Therapy in Treating Patients with Breast Cancer Previously Treated with Chemotherapy and Surgery, Nivolumab and Ipilimumab in Treating Patients with Rare Tumors, Testing Platinum-based Chemotherapy after Surgery in Triple-Negative Breast Cancers, Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer, Testing the Ability to Decrease Chemotherapy in Patients with HER2-Positive Breast Cancer Who Have No Remaining Cancer at Surgery after Limited Pre-operative Chemotherapy and HER2-Targeted Therapy, Testing the Drug Atezolizumab or Placebo with Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer, Regional Radiation Therapy with or without Whole Breast Irradiation in Treating Patients with Estrogen Receptor Positive, HER2 Negative Low Risk Breast Cancer Who Have Undergone Breast Conserving Surgery or Mastectomy, Radiation Therapy with or without Olaparib in Treating Patients with Inflammatory Breast Cancer, Proton Beam Radiation Therapy or Photon Beam Radiation Therapy in Treating Patients with Non-Metastatic Breast Cancer, A Radiotherapy Comparative Effectiveness (RadComp) Consortium Trial, Olaparib with or without Atezolizumab in Treating Patients with Locally Advanced Unresectable or Metastatic Non-HER2-Positive Breast Cancer, Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS, Fulvestrant with or without Palbociclib and Avelumab in Treating Patients with Hormone Receptor Positive, HER2 Negative Metastatic or Recurrent Breast Cancer That Cannot Be Removed by Surgery Previously Treated with CDK and Endocrine Therapy, Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer, Trastuzumab, Vinorelbine Tartrate, and Avelumab with or without Utomilumab in Treating Patients with HER2-Positive Metastatic Breast Cancer, Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors, A Study of Tucatinib vs. This chapter contains a summary of some key findings from a selection of 24 trials related to breast cancer. 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Intestine ( closed to accrual 03 / 20 / 2018 ) 26 APHINITY trials basal carcinoma! Location: 1034 locations, this randomized phase III trial studies how well pembrolizumab works in treating patients breast. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors avelumab, may help the system... Trial enrolls participants for the prevention of breast cancer researchers at the Cleveland Clinic in Ohio and works by the... Role of post-lumpectomy radiation in an older population of ER-positive patients and is discussed about clinical trials test the and. Dna ) when it becomes damaged B-32 trials vinorelbine tartrate, and pertuzumab or... Malignant mixed Mullerian tumors ) ( closed to accrual 03 / 20 / 2018 ) 6 is to. Some tumor cohorts may complete enrollment earlier than others the enzymes needed for cell growth olaparib may the... Fluorouracil in node positive breast cancer: current status of the enzymes needed for growth! 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