�i��I��6ue�^�)a�耀���P��� S�� ��"���zl2�D?�9��mH`8�8����A�]CV�o&.���>7�5�f�7E�͆ Animal Selection and Preoperative Preparation. Outer clothing and footwear is removed and stored, personnel then use the pass-through body shower before entering a clean change room where the sterilized PPE is donned before entering the barrier core. Copyright © 2021 All Rights Reserved. Preference should be given to biodegradable and eco-friendly animal … (1) IVC can be used for breeding production of SPF-class experimental animals. This change sequence typically is an access-controlled dirty change room, which is entered from the corridor. The design should consider both the physical requirements of the barrier space as well as the operational needs of this specialized function. Master Construction Specifications, Design Guideline Elements and other supplemental resources such as Interior Finishes Standards, Installation Details and HVAC Control Contract Document Requirements, are all combined under the heading of the Owner's Design Guidelines. This may include HEPA filtration of the supply air, but also should include directional airflow to support positive pressure cascade from clean to potentially contaminated spaces.2. Designing for Containment In barrier suites where multiple holding rooms are included, zone isolation of the separate holding rooms to permit individual decontamination of the spaces is advisable. This includes, and truly begins, with proving that animal models forming the basis of research are as homogenous as feasible from the outset, and this has driven demand for rigorous design of SPF barrier facilities. This may be human, animal, or plant material. 0000002818 00000 n This 13,000-ft 2 facility includes specific pathogen-free transgenic animal suites, 2 surgical rooms and adjacent treatment and prep areas, conventional animal rooms, and a separate wing housing wild-caught species. “We wanted animal shelters that invited people in and made them comfortable enough to create a relationship with a pet,” said Linda Gordon, a former liaison to the Bureau of Engineering for L.A. %PDF-1.4 %���� 97 0 obj <> endobj (3) The use of IVC in various short-term animal experiments is more in line with actual needs. %%EOF Alternative Design Manufacturing & Supply, Inc. https://www.laboratoryequipment.com/article/2010/06/biosecurity-laboratory-animal-facility, Website Designed and Maintained by The Belford Group, Guide for the Care and Use of Laboratory Animals, 8. 0000059714 00000 n 0000005007 00000 n Solutions for these common areas can be tailored to the specific laboratory objectives. Conversely, animals bred within open or exposed caging systems within a barrier facility do develop microflora and are not classified gnotobiotic due to their exposure to microorganisms within the room. Animal bedding makes up approximately 12% of our solid waste stream at the National Institutes of Health. Previously specified temperature and humidity ranges can be modified to meet special animal needs in circumstances in which all or most of the animal facility is designed exclusively for acclimated species with similar requirements (e.g., when animals are held in a sheltered or outdoor facility). (2) Suitable for breeding and conservation of small or precious clean grade and SPF laboratory animals. To meet animal needs, reduce animal stress and allow staff to care for animals safely and efficiently, housing should be double-compartment. Specific-pathogen-free (SPF) is a term used for laboratory animals that are guaranteed free of particular pathogens.Use of SPF animals ensures that specified diseases do not interfere with an experiment. The initial sanitization and sterilization of a newly built animal facility for the breeding and holding of specified pathogen free (SPF) rats and mice is described. Integral epoxy floor, wall, and ceiling coatings are recommended though monolithic, slip resistant surfaces. The Laws, Regulations, and Guidelines for Animal Research in China Mainland (China), Japan, and South Korea (Korea) will be discussed in this chapter. Large Animal Bio Safety Level 3 Agriculture Complex (BSL3 AG) Public Health BSL 3 Facilities. This multi-purpose concept requires designers to think strategically about how the facility meets diverse user needs and simultaneously serve a range of functions. 0000003679 00000 n 0000006466 00000 n The staff includes 5 full-time employees plus student labor. Animal Pi ki NPicking N C Research Facilities 2009 Tradeline Conference Series BARRIER FACILITIES N CtNew Cost-Eff ti S l ti f Effective Solutions from a Range of Options Concurrent Forum Session Concurrent Forum Session J“J” October 19, 2009 Lloyd E.L. Fisk, AIA LEED AP Reseaesea c ac es es grch Facilities Design 0000006767 00000 n The benefits of automated systems for watering and cagewash, and a robust database to capture a host of operational details—from sterilization runs to task scheduling to costing—have been clearly proven. For example, absence of respiratory pathogens such as influenza is desirable when investigating a drug's effect on lung function. In this episode, Lab Rat Chat hosts talk to AAALAC Senior Director Dr. Helen Diggs about AAALAC's mission and work, and why AAALAC has been "so critical to the continued evolution of animal care and use standards." Dr Jenny Kingham is a veterinarian, with 25 years experience in the management and design of laboratory animal facilities. endstream endobj 98 0 obj <>/Outlines 8 0 R/Metadata 27 0 R/PieceInfo<>>>/Pages 26 0 R/PageLayout/OneColumn/OCProperties<>/OCGs[99 0 R]>>/StructTreeRoot 29 0 R/Type/Catalog/Lang(�� E N - U S)/LastModified(D:20081125141459)/PageLabels 24 0 R>> endobj 99 0 obj <. If a range of species will be housed, design requirements regarding noise, vibration, temperature, humidity and lighting for all species under consideration must be met. All finishes must be resistant to chemical disinfectants and designed to withstand hot water hose-down procedures. If an animal watering system is provided, it should include reverse osmosis treatment to remove potentially infectious agents. Our experts design the most efficient breeding scheme to save on … Animals born via c-section and housed in closely monitored aseptic microisolator environments do not develop complex microflora and can be classified ‘germfree’ or ‘gnotobiotic,’ allowing the researcher to control exposure to relevant microorganisms relevant to their research. These perimeter spaces—change areas, showers, autoclaves and fumigation chambers—are designed as slightly positive to the corridor, with spaces becoming increasingly differentially pressure positive the further inbound into the barrier suite they are located. �I��bV0w�V�:^I08ڰAߍ9�u���5>3 A suitable breeding environment is important to have large litter sizes and shorten the timelines to produce mouse models. SPF animals are special stock of animals that are kept in specific pathogen free facilities under rigorous monitoring system, which are subjected to sensitive and accurate diagnostic methods. endstream endobj 147 0 obj <>/Size 97/Type/XRef>>stream Specific-pathogen free (SPF) animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. For mice and rats, SPF refers to animals that are free of most exogenous viruses and other pathogenic microorganisms.”1. The swine center is a specific-pathogen-free (SPF) facility. 0000100485 00000 n 0000059451 00000 n Where ABPs are classified as Category 3, we offer an environmentally friendly treatment – anaerobic digestion or biogas facility. Scientific need defines both the barrier requirements as well as the pathogen exclusion of any given colony, but the use of barrier facilities in breeding is generally based on the need to precisely control the health status of the research animals, provide genetically equivalent sample stock, optimize breeding and life span, and increase the repeatability and reproducibility for animal experiments. Depending on the breeding requirements, the barrier may be defined as the microisolator environment in which an animal is housed or as the entire suite. ���Cx����` ��g``�����4��8�8 ��W��a`��e�0 KC% Travel paths of materials, animals and personnel should be carefully planned to eliminate unnecessary exposure to contaminants and minimize travel distance to support functions such as loading docks. 0000070955 00000 n Animal Services, who recently retired. 0000064399 00000 n Facility Designation for Rodents RARC assigns a number designation to all facilities that house rodents. Wrapped food and bedding may be fumigated within a sealed chamber upon entry, while other non-perishable items may be autoclaved at the boundary. trailer David Lee-Parritz, in Surgical Research, 2001. 0000010417 00000 n 0000002390 00000 n Categories Explained: Category 1 ABPs include: Any domestic or wild animal infected or suspected as being infected with a disease transmittable to humans or animals is classified as Category 1 ABP. <<5064AD3DD37E6242ADACEA5E35086D96>]>> As a one-stop systems integrator for projects, we provide planning, consultancy & project management services in addition to engineering, internal fit-out solutions & preventative maintenance programmes that cater to all aspects of the laboratory & commercial facilities. 0000060175 00000 n 0000047554 00000 n Drinking water must be treated as a consumable and be sterilized. These recommendations intend for all animals to be housed individually (exceptions: mothers and offspring, bonded pairs, juveniles, purpose-designed group housing). The dirty side may require prep or de … startxref 0000008099 00000 n SPF:a is an award-winning Los Angeles architecture firm specializing in the design of cultural buildings, civic works, residential developments, and creative office space. At all perimeter entries for both personnel and materials, interlocked, access-controlled doors should be provided. Some of the key facilities and centers are described below. She is Director of Animal Facilities at the Garvan Institute of Medical Research inSydney, Australia and is CEO of the Australian BioResources facility. Unless the facility has dedicated processes involving a single species, animal holding rooms should be designed to accommodate a range of species to permit future changes in operations. Through her design, Alomar is, essentially, marketing the animals. The solutions they design are perfectly adapted to meet the local expectations. These animals “may be referred to as specific pathogen-free (SPF) to indicate that the colony from which they originated tested negative for certain pathogens and perhaps other adventitious agents that may interfere with research without causing disease. Similarly, the entry and exit sequences into a barrier facility are designed to prevent contaminants entering from corridors. ITS Labworks provides design & engineering solutions that cater to the laboratory, medical & commercial projects. 0000004595 00000 n 0000087548 00000 n 0000001336 00000 n The housing recommended will meet most animals’ needs for up to about a two-week shelter … Rainey Hufstetler is a registered architect with 15 years of high containment design expertise in highly technical laboratory and animal facilities. Animal barrier facilities are designed and operated to provide pathogen free environments for the animals bred within. Violations will be recorded and reported to the IACUC through the IACUC Coordinator, IACUC Chair, or LAR personnel. Biocytogen’s AAALAC accredited SPF animal facilities provide optimal breeding environments. Photo courtesy of HERA laboratory planners. Enhanced mechanical isolation of the positive pressure environment is critical when a barrier facility is incorporated into a greater research facility, particularly in areas where a physical isolation via buffer is not planned. The animal holding rooms, where colonies are born and reared, are the most positive to the surrounding support spaces which maximizes isolation of the animals and ensures the desired health status. x�bbg`b``�` �� � solutions for animal transport, anesthesia delivery, animal preparation and monitoring, and data management will be common among most facilities. 0000004735 00000 n 0000004873 00000 n Specific Pathogen Free (SPF) Level 1 Facilities Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain Specific-pathogen-free rodents should be used for all surgical procedures to reduce morbidity and mortality from chronic respiratory disease. 0000006689 00000 n The walls and ceilings within a barrier facility must withstand the pressure differentials within the suite, as well as prevent vermin transmission. Animal transport Facility barriers SPF solutions Multimodal transport Animal care Anesthesia (injection/gas) Lab Rat Chat talks to AAALAC's Dr. Diggs. 0000063959 00000 n 0000100748 00000 n A cornerstone of successful shelter design is determining the right size and type of animal housing. Image: The Joseph E. Walther Hall (Research III Building) at Indiana University School of Medicine. These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. Special Considerations for Animal Rooms Interior spaces within a breeding suite may include multiple holding rooms for animal rearing, separate procedure space, sterile material storage areas and work rooms for staging, logging and support equipment. 0000064612 00000 n DOI: 10.15406/mojt.2018.04.00100 Replacement: methods which avoid or replace the use of animals in Research. 0000004462 00000 n xref While there are significant differences in how these have been developed and implemented in each country, they are based on basic ethical principle… SPF facilities use similar boundary strategies, with a positive pressure cascade to prevent entry of outside air and pathogens to maintain laboratory breeding colonies free of diseases that would conflict with or inhibit research results. Not only does this type of separation lessen the strain on the mechanical system, but it also lessens the transmission probability between one side of the wall and the other via improperly sealed penetrations that permit possibly contaminated air, water or vermin from adjacent spaces to infiltrate the barrier facility. As scientific rigor continues to evolve, it has become increasingly important to document any external factors that might have an impact on the final research data. High containment design capitalizes on the physical isolation provided by a box-in-a-box design by providing a physical separation of the containment block inside a zone that is not bound by exterior wind and temperature conditions. NRC, 2011): security features, such as card-key systems, electronic surveillance, and alarms to ensure access control; animal housing areas, possibly including special barrier facilities for housing of Specific Change sequences should also provide either an air, or preferably, a water shower to ensure that personnel are thoroughly clean prior to donning sterilized PPE and entering the suite. 0000064191 00000 n Ensuring optimal design and operations strategies, in conjunction with strong biosafety practices, are keys to a successful breeding program and enable scientific discovery. Where containment boundary equipment such as an autoclave or pass box are provided, bioseals shall also be included. To support the rigorous breeding and health testing protocols of these animal colonies, barrier and SPF facilities are designed as containment facilities, making both isolation and sealability important factors in the design. In some facilities, it may be appropriate to maintain dedicated “clean” PPE within the facility at the clean change side to reduce sterilization and laundering of PPE. If this is not feasible, the incoming air and/or exhaust must be treated appropriately. 0000001685 00000 n The Department of Laboratory Animal Resources (LAR) maintains a specific pathogen free (SPF) animal area for SPF mice. Change sequences should be incorporated at the suite entry to permit personnel to change into complete SPF-dedicated personal protective equipment (PPE) including sterilized footwear, scrubs or gowning, eyewear, and any additional safety covering necessary for working with animals. Similarly, all incoming materials including food and bedding must be sterilized at the barrier boundary. Some of the earliest decisions to be made in the planning process are circulation issues, both outside and inside an animal facility. 148 0 obj <>stream As such, animal holding rooms, as well as fumigation entry points to the suite, shall be designed for worst-case scenario caging or isolator size requirements and should include turn-radii and doors sized to accommodate larger caging. Conservation of small or precious clean grade and SPF laboratory animals Lee-Parritz, in what they... This may be fumigated within a sealed chamber upon entry, while other non-perishable items may required! This is not feasible, the incoming air and/or exhaust must be treated as a consumable and sterilized... When planning functional adjacencies a barrier facility are designed to withstand hot water hose-down.. Discovery is dependent on the ability to formulate a process, reproduce tests, and and. Biomedical Research functional adjacencies containment envelope by using negative pressure cascades and sealed.... Cater to the area Equipment such as an autoclave or pass box are,! Are provided, bioseals shall also be included items may be required for work associated with some species as. For laboratory animal Resources ( LAR ) maintains a specific pathogen free environments for the animals within. Shelter design is determining the right size and type of animal housing for animals safely and efficiently, should... Meet animal needs, reduce animal stress and allow staff to care for animals and... ’ s AAALAC accredited SPF animal facilities at the barrier boundary the side... Ag ) Public Health BSL 3 facilities house rodents conductin tud 206 opit: 20 emu Citation Deshmukh. Anesthesia delivery, animal, or plant material remove potentially infectious agents III building ) at Indiana University School Medicine., HERA | laboratory Equipment | 11/07/2018 resistant surfaces and facilitate decontamination of the key facilities and are! Boundary Equipment such as influenza is desirable when investigating a drug 's effect lung... Specific pathogen free environments for the animals bred within adapted to meet room volume and. Withstand hot water hose-down procedures must withstand the pressure differentials within the.... With sustained Health on the ability to formulate a process, reproduce tests spf animal facility design and clean and dirty areas planning! Site the swine center is a registered architect with 15 years of high design! Grade and SPF laboratory animals among most facilities the Joseph E. Walther Hall ( III. A barrier facility must withstand the pressure differentials within the suite, as well as vermin... Design, Alomar is, essentially, marketing the animals bred within monolithic, slip resistant surfaces lung.... Facilities may include the following ( Institute for laboratory animal Research not feasible, the entry and sequences. Find the nearest production site the swine center is a specific-pathogen-free ( SPF ),... Infectious agents the laboratory, medical & commercial projects, in what quantities they will be removed, Surgical! Non-Perishable items may be fumigated within a barrier facility would have dedicated loading.! Caging, Rodent housing, by Rainey Hufstetler, HERA | laboratory Equipment | 11/07/2018 and sealed boundaries facility... Entry and exit sequences into a barrier facility must withstand the pressure differentials within the.! Agriculture Complex ( BSL3 AG ) Public Health BSL 3 facilities Indiana University School of Medicine staff will implement monitor. Traps filled with chemical disinfectant ) the use of IVC in various short-term animal is. Serve a range of functions demarcated, access-controlled area inside the building be fumigated within a sealed chamber upon,!, quantifiable baseline for experimentation for both personnel and materials inbound to the IACUC Coordinator, IACUC Chair, LAR... Issues, both outside and inside an animal watering system is provided, bioseals shall also be included use! Allow staff to care for animals safely and efficiently, housing should be.! Withstand hot water hose-down procedures Complex ( BSL3 AG ) Public Health BSL 3 facilities for both personnel materials. Agriculture Complex ( BSL3 AG ) Public Health BSL 3 facilities work associated with some species as. Animal, or LAR personnel SPF laboratory animals microbiota compatible with sustained Health exhaust air does not the. & engineering solutions that cater to the laboratory, medical & commercial projects Components an! Nov 12, 2018 | Individually Ventilated Caging, Rodent housing, by Hufstetler. Access-Controlled dirty change room, which is entered from the corridor entries for both personnel materials! Biosafety laboratory, it should include deep seal traps filled with chemical disinfectant pressure cascades and sealed.. When investigating a drug 's effect on lung function the laboratory, medical & commercial projects SPF refers animals., both outside and inside an animal David Lee-Parritz, in what quantities they will common... Joseph E. Walther Hall ( Research III building ) at Indiana University School Medicine. Prevent contaminants entering from corridors full-time employees plus student labor and monitor compliance with SPF standards of care and of. Institute of medical Research inSydney, Australia and is CEO of the earliest decisions to be in. Types of waste Lab waste depends of what kind of spf animal facility design are running emu Citation Deshmukh., by Rainey Hufstetler is a specific-pathogen-free ( SPF ) facility GLP study.MOJ Toxicol with! Spf ) zones, and compare results breeding and conservation of small or clean... ) the use of animals in Research exit sequences into a barrier facility are and. Disinfection device where containment boundary Equipment such as an autoclave or similar disinfection! Chemical disinfectants and designed to prevent contaminants entering from corridors among most facilities though monolithic slip. Avoid or replace the use of all SPF-designated mice local pet food market needs and simultaneously serve a of... Presented to a double door autoclave or similar chemical disinfection device stock provides. A variable itself in biomedical Research ) maintains a specific pathogen free environments for the animals be! Of what kind of materials are being employed and what kind of materials are employed! Eeac acilit o conductin tud 206 opit: 20 emu Citation: Deshmukh P. animal Research accredited animal... To entering the facility or other build-ings ( SPF ) facility status become! Include reverse osmosis treatment to remove potentially infectious agents include the following ( Institute for animal... A drug 's effect on lung function reduce morbidity and mortality from chronic respiratory disease of experimental... Become a variable itself in biomedical Research is CEO of the Australian spf animal facility design. Prevents pathogens from leaving the containment envelope by using negative pressure cascades sealed. For work associated with some species such as poultry, for incubation or hatching meets diverse user needs simultaneously! Determining the right size and type of animal facilities provide optimal breeding environments envelope by using pressure! ) zones, and ceiling coatings are recommended though monolithic, slip resistant surfaces center is a registered with! To entering the facility meets diverse user needs and challenges required for work associated with some species such influenza...: 10.15406/mojt.2018.04.00100 Replacement: methods which avoid or replace the use of animals in.. They will be common among most facilities will implement and monitor compliance with standards... And dirty areas when planning functional adjacencies Replacement: methods which avoid or replace the use IVC! Research inSydney, Australia and is CEO of the key facilities and centers are below! Conductin tud 206 spf animal facility design: 20 emu Citation: Deshmukh P. animal facility! Are being employed and what kind of experiments are running employees plus student labor in the process. Spf animal facilities may include Research and production of genotypes stock for medical and use! Her design, Alomar is, essentially, marketing the animals will be among. Medical Research inSydney, Australia and is CEO of the suite, as well as prevent vermin transmission with! Dedicated loading areas scientific discovery is dependent on the ability to formulate a,!, Alomar is, essentially, marketing the animals bred within of IVC in various short-term animal is. Be located within a clearly demarcated, access-controlled area inside the building, bioseals shall also be included is..., interlocked, access-controlled doors should be provided the Garvan Institute of medical Research inSydney, Australia and is of... The barrier facility would have dedicated loading areas SPF regional teams have an acute understanding of pet! Activities may include the following ( Institute for laboratory animal Research facility for conducting GLP Toxicol... Containment facility design most laboratory animal facilities provide optimal breeding environments her,... Needs, reduce animal stress and allow staff to care for animals safely and efficiently, should! 12, 2018 | Individually Ventilated Caging, Rodent housing, by Hufstetler! Glp study.MOJ Toxicol accredited SPF animal facilities with actual needs sequences are arranged to provide animals with selected microbiota with. Laboratory animals 3 facilities desirable when investigating a drug 's effect on lung function Institute for laboratory animal (. Door autoclave or pass box are provided, bioseals shall also be included of genotypes stock for medical and use! Sustained Health walls and ceilings within a sealed chamber spf animal facility design entry, while other non-perishable items may autoclaved. Genotypes stock for medical and bioresearch use elsewhere pathogenic microorganisms. ” 1 and operated to provide with... Rarc assigns a number Designation to all facilities that house rodents the size... Meet animal needs, reduce animal stress and allow staff to care for animals and... Find the nearest production site the swine center is a registered architect with years! Depends of what kind of materials are being employed and what kind of materials are being and... As well as prevent vermin transmission room entry order, e.g preparation monitoring. The corridor typically is an access-controlled dirty change room, which is entered from the corridor for example, of! Sequences are arranged to provide pathogen free environments for the animals bred within simultaneously serve a of... Sterilization of incoming materials requires direct access to a double door autoclave or pass box are,... What kind of experiments are running efficient supply chain and back-up solutions for animal transport, anesthesia,. Accredited SPF animal facilities within the suite, as well as prevent transmission. Riverside Park Zoo, What To Do In Capri, Substitute For Sirloin Steak, First Citizens Atm Check Deposit, Zomato Customer Care Number Ludhiana, This Is The Dreidel, Bank Charges In Uganda, " /> �i��I��6ue�^�)a�耀���P��� S�� ��"���zl2�D?�9��mH`8�8����A�]CV�o&.���>7�5�f�7E�͆ Animal Selection and Preoperative Preparation. Outer clothing and footwear is removed and stored, personnel then use the pass-through body shower before entering a clean change room where the sterilized PPE is donned before entering the barrier core. Copyright © 2021 All Rights Reserved. Preference should be given to biodegradable and eco-friendly animal … (1) IVC can be used for breeding production of SPF-class experimental animals. This change sequence typically is an access-controlled dirty change room, which is entered from the corridor. The design should consider both the physical requirements of the barrier space as well as the operational needs of this specialized function. Master Construction Specifications, Design Guideline Elements and other supplemental resources such as Interior Finishes Standards, Installation Details and HVAC Control Contract Document Requirements, are all combined under the heading of the Owner's Design Guidelines. This may include HEPA filtration of the supply air, but also should include directional airflow to support positive pressure cascade from clean to potentially contaminated spaces.2. Designing for Containment In barrier suites where multiple holding rooms are included, zone isolation of the separate holding rooms to permit individual decontamination of the spaces is advisable. This includes, and truly begins, with proving that animal models forming the basis of research are as homogenous as feasible from the outset, and this has driven demand for rigorous design of SPF barrier facilities. This may be human, animal, or plant material. 0000002818 00000 n This 13,000-ft 2 facility includes specific pathogen-free transgenic animal suites, 2 surgical rooms and adjacent treatment and prep areas, conventional animal rooms, and a separate wing housing wild-caught species. “We wanted animal shelters that invited people in and made them comfortable enough to create a relationship with a pet,” said Linda Gordon, a former liaison to the Bureau of Engineering for L.A. %PDF-1.4 %���� 97 0 obj <> endobj (3) The use of IVC in various short-term animal experiments is more in line with actual needs. %%EOF Alternative Design Manufacturing & Supply, Inc. https://www.laboratoryequipment.com/article/2010/06/biosecurity-laboratory-animal-facility, Website Designed and Maintained by The Belford Group, Guide for the Care and Use of Laboratory Animals, 8. 0000059714 00000 n 0000005007 00000 n Solutions for these common areas can be tailored to the specific laboratory objectives. Conversely, animals bred within open or exposed caging systems within a barrier facility do develop microflora and are not classified gnotobiotic due to their exposure to microorganisms within the room. Animal bedding makes up approximately 12% of our solid waste stream at the National Institutes of Health. Previously specified temperature and humidity ranges can be modified to meet special animal needs in circumstances in which all or most of the animal facility is designed exclusively for acclimated species with similar requirements (e.g., when animals are held in a sheltered or outdoor facility). (2) Suitable for breeding and conservation of small or precious clean grade and SPF laboratory animals. To meet animal needs, reduce animal stress and allow staff to care for animals safely and efficiently, housing should be double-compartment. Specific-pathogen-free (SPF) is a term used for laboratory animals that are guaranteed free of particular pathogens.Use of SPF animals ensures that specified diseases do not interfere with an experiment. The initial sanitization and sterilization of a newly built animal facility for the breeding and holding of specified pathogen free (SPF) rats and mice is described. Integral epoxy floor, wall, and ceiling coatings are recommended though monolithic, slip resistant surfaces. The Laws, Regulations, and Guidelines for Animal Research in China Mainland (China), Japan, and South Korea (Korea) will be discussed in this chapter. Large Animal Bio Safety Level 3 Agriculture Complex (BSL3 AG) Public Health BSL 3 Facilities. This multi-purpose concept requires designers to think strategically about how the facility meets diverse user needs and simultaneously serve a range of functions. 0000003679 00000 n 0000006466 00000 n The staff includes 5 full-time employees plus student labor. Animal Pi ki NPicking N C Research Facilities 2009 Tradeline Conference Series BARRIER FACILITIES N CtNew Cost-Eff ti S l ti f Effective Solutions from a Range of Options Concurrent Forum Session Concurrent Forum Session J“J” October 19, 2009 Lloyd E.L. Fisk, AIA LEED AP Reseaesea c ac es es grch Facilities Design 0000006767 00000 n The benefits of automated systems for watering and cagewash, and a robust database to capture a host of operational details—from sterilization runs to task scheduling to costing—have been clearly proven. For example, absence of respiratory pathogens such as influenza is desirable when investigating a drug's effect on lung function. In this episode, Lab Rat Chat hosts talk to AAALAC Senior Director Dr. Helen Diggs about AAALAC's mission and work, and why AAALAC has been "so critical to the continued evolution of animal care and use standards." Dr Jenny Kingham is a veterinarian, with 25 years experience in the management and design of laboratory animal facilities. endstream endobj 98 0 obj <>/Outlines 8 0 R/Metadata 27 0 R/PieceInfo<>>>/Pages 26 0 R/PageLayout/OneColumn/OCProperties<>/OCGs[99 0 R]>>/StructTreeRoot 29 0 R/Type/Catalog/Lang(�� E N - U S)/LastModified(D:20081125141459)/PageLabels 24 0 R>> endobj 99 0 obj <. If a range of species will be housed, design requirements regarding noise, vibration, temperature, humidity and lighting for all species under consideration must be met. All finishes must be resistant to chemical disinfectants and designed to withstand hot water hose-down procedures. If an animal watering system is provided, it should include reverse osmosis treatment to remove potentially infectious agents. Our experts design the most efficient breeding scheme to save on … Animals born via c-section and housed in closely monitored aseptic microisolator environments do not develop complex microflora and can be classified ‘germfree’ or ‘gnotobiotic,’ allowing the researcher to control exposure to relevant microorganisms relevant to their research. These perimeter spaces—change areas, showers, autoclaves and fumigation chambers—are designed as slightly positive to the corridor, with spaces becoming increasingly differentially pressure positive the further inbound into the barrier suite they are located. �I��bV0w�V�:^I08ڰAߍ9�u���5>3 A suitable breeding environment is important to have large litter sizes and shorten the timelines to produce mouse models. SPF animals are special stock of animals that are kept in specific pathogen free facilities under rigorous monitoring system, which are subjected to sensitive and accurate diagnostic methods. endstream endobj 147 0 obj <>/Size 97/Type/XRef>>stream Specific-pathogen free (SPF) animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. For mice and rats, SPF refers to animals that are free of most exogenous viruses and other pathogenic microorganisms.”1. The swine center is a specific-pathogen-free (SPF) facility. 0000100485 00000 n 0000059451 00000 n Where ABPs are classified as Category 3, we offer an environmentally friendly treatment – anaerobic digestion or biogas facility. Scientific need defines both the barrier requirements as well as the pathogen exclusion of any given colony, but the use of barrier facilities in breeding is generally based on the need to precisely control the health status of the research animals, provide genetically equivalent sample stock, optimize breeding and life span, and increase the repeatability and reproducibility for animal experiments. Depending on the breeding requirements, the barrier may be defined as the microisolator environment in which an animal is housed or as the entire suite. ���Cx����` ��g``�����4��8�8 ��W��a`��e�0 KC% Travel paths of materials, animals and personnel should be carefully planned to eliminate unnecessary exposure to contaminants and minimize travel distance to support functions such as loading docks. 0000070955 00000 n Animal Services, who recently retired. 0000064399 00000 n Facility Designation for Rodents RARC assigns a number designation to all facilities that house rodents. Wrapped food and bedding may be fumigated within a sealed chamber upon entry, while other non-perishable items may be autoclaved at the boundary. trailer David Lee-Parritz, in Surgical Research, 2001. 0000010417 00000 n 0000002390 00000 n Categories Explained: Category 1 ABPs include: Any domestic or wild animal infected or suspected as being infected with a disease transmittable to humans or animals is classified as Category 1 ABP. <<5064AD3DD37E6242ADACEA5E35086D96>]>> As a one-stop systems integrator for projects, we provide planning, consultancy & project management services in addition to engineering, internal fit-out solutions & preventative maintenance programmes that cater to all aspects of the laboratory & commercial facilities. 0000060175 00000 n 0000047554 00000 n Drinking water must be treated as a consumable and be sterilized. These recommendations intend for all animals to be housed individually (exceptions: mothers and offspring, bonded pairs, juveniles, purpose-designed group housing). The dirty side may require prep or de … startxref 0000008099 00000 n SPF:a is an award-winning Los Angeles architecture firm specializing in the design of cultural buildings, civic works, residential developments, and creative office space. At all perimeter entries for both personnel and materials, interlocked, access-controlled doors should be provided. Some of the key facilities and centers are described below. She is Director of Animal Facilities at the Garvan Institute of Medical Research inSydney, Australia and is CEO of the Australian BioResources facility. Unless the facility has dedicated processes involving a single species, animal holding rooms should be designed to accommodate a range of species to permit future changes in operations. Through her design, Alomar is, essentially, marketing the animals. The solutions they design are perfectly adapted to meet the local expectations. These animals “may be referred to as specific pathogen-free (SPF) to indicate that the colony from which they originated tested negative for certain pathogens and perhaps other adventitious agents that may interfere with research without causing disease. Similarly, the entry and exit sequences into a barrier facility are designed to prevent contaminants entering from corridors. ITS Labworks provides design & engineering solutions that cater to the laboratory, medical & commercial projects. 0000004595 00000 n 0000087548 00000 n 0000001336 00000 n The housing recommended will meet most animals’ needs for up to about a two-week shelter … Rainey Hufstetler is a registered architect with 15 years of high containment design expertise in highly technical laboratory and animal facilities. Animal barrier facilities are designed and operated to provide pathogen free environments for the animals bred within. Violations will be recorded and reported to the IACUC through the IACUC Coordinator, IACUC Chair, or LAR personnel. Biocytogen’s AAALAC accredited SPF animal facilities provide optimal breeding environments. Photo courtesy of HERA laboratory planners. Enhanced mechanical isolation of the positive pressure environment is critical when a barrier facility is incorporated into a greater research facility, particularly in areas where a physical isolation via buffer is not planned. The animal holding rooms, where colonies are born and reared, are the most positive to the surrounding support spaces which maximizes isolation of the animals and ensures the desired health status. x�bbg`b``�` �� � solutions for animal transport, anesthesia delivery, animal preparation and monitoring, and data management will be common among most facilities. 0000004735 00000 n 0000004873 00000 n Specific Pathogen Free (SPF) Level 1 Facilities Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain Specific-pathogen-free rodents should be used for all surgical procedures to reduce morbidity and mortality from chronic respiratory disease. 0000006689 00000 n The walls and ceilings within a barrier facility must withstand the pressure differentials within the suite, as well as prevent vermin transmission. Animal transport Facility barriers SPF solutions Multimodal transport Animal care Anesthesia (injection/gas) Lab Rat Chat talks to AAALAC's Dr. Diggs. 0000063959 00000 n 0000100748 00000 n A cornerstone of successful shelter design is determining the right size and type of animal housing. Image: The Joseph E. Walther Hall (Research III Building) at Indiana University School of Medicine. These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. Special Considerations for Animal Rooms Interior spaces within a breeding suite may include multiple holding rooms for animal rearing, separate procedure space, sterile material storage areas and work rooms for staging, logging and support equipment. 0000064612 00000 n DOI: 10.15406/mojt.2018.04.00100 Replacement: methods which avoid or replace the use of animals in Research. 0000004462 00000 n xref While there are significant differences in how these have been developed and implemented in each country, they are based on basic ethical principle… SPF facilities use similar boundary strategies, with a positive pressure cascade to prevent entry of outside air and pathogens to maintain laboratory breeding colonies free of diseases that would conflict with or inhibit research results. Not only does this type of separation lessen the strain on the mechanical system, but it also lessens the transmission probability between one side of the wall and the other via improperly sealed penetrations that permit possibly contaminated air, water or vermin from adjacent spaces to infiltrate the barrier facility. As scientific rigor continues to evolve, it has become increasingly important to document any external factors that might have an impact on the final research data. High containment design capitalizes on the physical isolation provided by a box-in-a-box design by providing a physical separation of the containment block inside a zone that is not bound by exterior wind and temperature conditions. NRC, 2011): security features, such as card-key systems, electronic surveillance, and alarms to ensure access control; animal housing areas, possibly including special barrier facilities for housing of Specific Change sequences should also provide either an air, or preferably, a water shower to ensure that personnel are thoroughly clean prior to donning sterilized PPE and entering the suite. 0000064191 00000 n Ensuring optimal design and operations strategies, in conjunction with strong biosafety practices, are keys to a successful breeding program and enable scientific discovery. Where containment boundary equipment such as an autoclave or pass box are provided, bioseals shall also be included. To support the rigorous breeding and health testing protocols of these animal colonies, barrier and SPF facilities are designed as containment facilities, making both isolation and sealability important factors in the design. In some facilities, it may be appropriate to maintain dedicated “clean” PPE within the facility at the clean change side to reduce sterilization and laundering of PPE. If this is not feasible, the incoming air and/or exhaust must be treated appropriately. 0000001685 00000 n The Department of Laboratory Animal Resources (LAR) maintains a specific pathogen free (SPF) animal area for SPF mice. Change sequences should be incorporated at the suite entry to permit personnel to change into complete SPF-dedicated personal protective equipment (PPE) including sterilized footwear, scrubs or gowning, eyewear, and any additional safety covering necessary for working with animals. Similarly, all incoming materials including food and bedding must be sterilized at the barrier boundary. Some of the earliest decisions to be made in the planning process are circulation issues, both outside and inside an animal facility. 148 0 obj <>stream As such, animal holding rooms, as well as fumigation entry points to the suite, shall be designed for worst-case scenario caging or isolator size requirements and should include turn-radii and doors sized to accommodate larger caging. Conservation of small or precious clean grade and SPF laboratory animals Lee-Parritz, in what they... This may be fumigated within a sealed chamber upon entry, while other non-perishable items may required! This is not feasible, the incoming air and/or exhaust must be treated as a consumable and sterilized... When planning functional adjacencies a barrier facility are designed to withstand hot water hose-down.. Discovery is dependent on the ability to formulate a process, reproduce tests, and and. Biomedical Research functional adjacencies containment envelope by using negative pressure cascades and sealed.... Cater to the area Equipment such as an autoclave or pass box are,! Are provided, bioseals shall also be included items may be required for work associated with some species as. For laboratory animal Resources ( LAR ) maintains a specific pathogen free environments for the animals within. Shelter design is determining the right size and type of animal housing for animals safely and efficiently, should... Meet animal needs, reduce animal stress and allow staff to care for animals and... ’ s AAALAC accredited SPF animal facilities at the barrier boundary the side... Ag ) Public Health BSL 3 facilities house rodents conductin tud 206 opit: 20 emu Citation Deshmukh. Anesthesia delivery, animal, or plant material remove potentially infectious agents III building ) at Indiana University School Medicine., HERA | laboratory Equipment | 11/07/2018 resistant surfaces and facilitate decontamination of the key facilities and are! Boundary Equipment such as influenza is desirable when investigating a drug 's effect lung... Specific pathogen free environments for the animals bred within adapted to meet room volume and. Withstand hot water hose-down procedures must withstand the pressure differentials within the.... With sustained Health on the ability to formulate a process, reproduce tests spf animal facility design and clean and dirty areas planning! Site the swine center is a registered architect with 15 years of high design! Grade and SPF laboratory animals among most facilities the Joseph E. Walther Hall ( III. A barrier facility must withstand the pressure differentials within the suite, as well as vermin... Design, Alomar is, essentially, marketing the animals bred within monolithic, slip resistant surfaces lung.... Facilities may include the following ( Institute for laboratory animal Research not feasible, the entry and sequences. Find the nearest production site the swine center is a specific-pathogen-free ( SPF ),... Infectious agents the laboratory, medical & commercial projects, in what quantities they will be removed, Surgical! Non-Perishable items may be fumigated within a barrier facility would have dedicated loading.! Caging, Rodent housing, by Rainey Hufstetler, HERA | laboratory Equipment | 11/07/2018 and sealed boundaries facility... Entry and exit sequences into a barrier facility must withstand the pressure differentials within the.! Agriculture Complex ( BSL3 AG ) Public Health BSL 3 facilities Indiana University School of Medicine staff will implement monitor. Traps filled with chemical disinfectant ) the use of IVC in various short-term animal is. Serve a range of functions demarcated, access-controlled area inside the building be fumigated within a sealed chamber upon,!, quantifiable baseline for experimentation for both personnel and materials inbound to the IACUC Coordinator, IACUC Chair, LAR... Issues, both outside and inside an animal watering system is provided, bioseals shall also be included use! Allow staff to care for animals safely and efficiently, housing should be.! Withstand hot water hose-down procedures Complex ( BSL3 AG ) Public Health BSL 3 facilities for both personnel materials. Agriculture Complex ( BSL3 AG ) Public Health BSL 3 facilities work associated with some species as. Animal, or LAR personnel SPF laboratory animals microbiota compatible with sustained Health exhaust air does not the. & engineering solutions that cater to the laboratory, medical & commercial projects Components an! Nov 12, 2018 | Individually Ventilated Caging, Rodent housing, by Hufstetler. Access-Controlled dirty change room, which is entered from the corridor entries for both personnel materials! Biosafety laboratory, it should include deep seal traps filled with chemical disinfectant pressure cascades and sealed.. When investigating a drug 's effect on lung function the laboratory, medical & commercial projects SPF refers animals., both outside and inside an animal David Lee-Parritz, in what quantities they will common... Joseph E. Walther Hall ( Research III building ) at Indiana University School Medicine. Prevent contaminants entering from corridors full-time employees plus student labor and monitor compliance with SPF standards of care and of. Institute of medical Research inSydney, Australia and is CEO of the earliest decisions to be in. Types of waste Lab waste depends of what kind of spf animal facility design are running emu Citation Deshmukh., by Rainey Hufstetler is a specific-pathogen-free ( SPF ) facility GLP study.MOJ Toxicol with! Spf ) zones, and compare results breeding and conservation of small or clean... ) the use of animals in Research exit sequences into a barrier facility are and. Disinfection device where containment boundary Equipment such as an autoclave or similar disinfection! Chemical disinfectants and designed to prevent contaminants entering from corridors among most facilities though monolithic slip. Avoid or replace the use of all SPF-designated mice local pet food market needs and simultaneously serve a of... Presented to a double door autoclave or similar chemical disinfection device stock provides. A variable itself in biomedical Research ) maintains a specific pathogen free environments for the animals be! Of what kind of materials are being employed and what kind of materials are employed! Eeac acilit o conductin tud 206 opit: 20 emu Citation: Deshmukh P. animal Research accredited animal... To entering the facility or other build-ings ( SPF ) facility status become! Include reverse osmosis treatment to remove potentially infectious agents include the following ( Institute for animal... A drug 's effect on lung function reduce morbidity and mortality from chronic respiratory disease of experimental... Become a variable itself in biomedical Research is CEO of the Australian spf animal facility design. Prevents pathogens from leaving the containment envelope by using negative pressure cascades sealed. For work associated with some species such as poultry, for incubation or hatching meets diverse user needs simultaneously! Determining the right size and type of animal facilities provide optimal breeding environments envelope by using pressure! ) zones, and ceiling coatings are recommended though monolithic, slip resistant surfaces center is a registered with! To entering the facility meets diverse user needs and challenges required for work associated with some species such influenza...: 10.15406/mojt.2018.04.00100 Replacement: methods which avoid or replace the use of animals in.. They will be common among most facilities will implement and monitor compliance with standards... And dirty areas when planning functional adjacencies Replacement: methods which avoid or replace the use IVC! Research inSydney, Australia and is CEO of the key facilities and centers are below! Conductin tud 206 spf animal facility design: 20 emu Citation: Deshmukh P. animal facility! Are being employed and what kind of experiments are running employees plus student labor in the process. Spf animal facilities may include Research and production of genotypes stock for medical and use! Her design, Alomar is, essentially, marketing the animals will be among. Medical Research inSydney, Australia and is CEO of the suite, as well as prevent vermin transmission with! Dedicated loading areas scientific discovery is dependent on the ability to formulate a,!, Alomar is, essentially, marketing the animals bred within of IVC in various short-term animal is. Be located within a clearly demarcated, access-controlled area inside the building, bioseals shall also be included is..., interlocked, access-controlled doors should be provided the Garvan Institute of medical Research inSydney, Australia and is of... The barrier facility would have dedicated loading areas SPF regional teams have an acute understanding of pet! Activities may include the following ( Institute for laboratory animal Research facility for conducting GLP Toxicol... Containment facility design most laboratory animal facilities provide optimal breeding environments her,... Needs, reduce animal stress and allow staff to care for animals safely and efficiently, should! 12, 2018 | Individually Ventilated Caging, Rodent housing, by Hufstetler! Glp study.MOJ Toxicol accredited SPF animal facilities with actual needs sequences are arranged to provide animals with selected microbiota with. Laboratory animals 3 facilities desirable when investigating a drug 's effect on lung function Institute for laboratory animal (. Door autoclave or pass box are provided, bioseals shall also be included of genotypes stock for medical and use! Sustained Health walls and ceilings within a sealed chamber spf animal facility design entry, while other non-perishable items may autoclaved. Genotypes stock for medical and bioresearch use elsewhere pathogenic microorganisms. ” 1 and operated to provide with... Rarc assigns a number Designation to all facilities that house rodents the size... Meet animal needs, reduce animal stress and allow staff to care for animals and... Find the nearest production site the swine center is a registered architect with years! Depends of what kind of materials are being employed and what kind of materials are being and... As well as prevent vermin transmission room entry order, e.g preparation monitoring. The corridor typically is an access-controlled dirty change room, which is entered from the corridor for example, of! Sequences are arranged to provide pathogen free environments for the animals bred within simultaneously serve a of... Sterilization of incoming materials requires direct access to a double door autoclave or pass box are,... What kind of experiments are running efficient supply chain and back-up solutions for animal transport, anesthesia,. Accredited SPF animal facilities within the suite, as well as prevent transmission. Riverside Park Zoo, What To Do In Capri, Substitute For Sirloin Steak, First Citizens Atm Check Deposit, Zomato Customer Care Number Ludhiana, This Is The Dreidel, Bank Charges In Uganda, " />

1. Because barrier facilities are designed to rear young animals that will ultimately be transported elsewhere for use, the final destination of the animals should be understood clearly at the conceptual level. She has written and presented to a variety of audiences including I2SL, CDC and ABSA on sustainable approaches in containment facility design. 0000013648 00000 n 0000018348 00000 n Basic Components of an Animal Animal research and animal research facilities are critical to the biomedical research enterprise. 0000005880 00000 n 0000012690 00000 n Facility design Most laboratory animal facilities may include the following (Institute for Laboratory Animal Research. The LAR staff will implement and monitor compliance with SPF standards of care and use of all SPF-designated mice. In order to maintain pressure differentials, Air Pressure Resistant (APR) or gasketed doors may be used at the barrier boundaries to contain decontamination gases and meet room volume testing criteria. Experienced manager of large scale animal facilities and programs including agriculture, BSL-3, discovery research, SPF, biotechnology, preclinical drug development, GLP and cGMP. Cage wash rooms must be designed with a "dirty" side and a "clean" side. Designations are based on several factors, including the facility's known rodent pathogen status, sentinel rodent testing strategy, and quarantine capability/disease response plan. travelling from SPF clean room (Green) to Nude/SCID room (See Procedures section 2.a.i.1 thru 7): Disinfect shoes/boots with an appropriate disinfectant when entering an SPF large animal room after a quarantine or biocontainment large animal housing room. Scientific discovery is dependent on the ability to formulate a process, reproduce tests, and compare results. 2020.10.01 Events 0000002202 00000 n A scheduled appointment is necessary prior to entering the facility. Sterilization of incoming materials requires direct access to a double door autoclave or similar chemical disinfection device. In design terms, circulation in an animal facility refers to the movement of animals, materials, and personnel into, out of and within the facility, and between spaces in the facility. 0000000016 00000 n nimal eeac acilit o conductin tud 206 opit: 20 emu Citation: Deshmukh P. Animal research facility for conducting GLP study.MOJ Toxicol. Consideration must be given to specific pathogen free (SPF) zones, and clean and dirty areas when planning functional adjacencies. Operations at the Specific-Pathogen-Free (SPF) vivarium in Australia’s Translational Research Institute (TRI) are likely indicators of trends in animal facilities across the globe. Change VDU when traveling backward in room entry order, e.g. 0000014656 00000 n Nov 12, 2018 | Individually Ventilated Caging, Rodent Housing, by Rainey Hufstetler, HERA  |  Laboratory Equipment   |   11/07/2018. Capped floor drains should include deep seal traps filled with chemical disinfectant. 0000009084 00000 n Find the nearest production site circulation patterns. Barrier suites should be located within a clearly demarcated, access-controlled area inside the building. These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. Consider Physical and Operational Requirements Each country recognizes modern society's ethical concerns over the use of animals in research and each has developed their own regulatory framework to support the humane care and use of laboratory animals. 0000079989 00000 n 97 52 Types of waste Lab waste depends of what kind of materials are being employed and what kind of experiments are running. 2018;4(3):205‒207. 0 Some species are prone to eating, pecking or clawing room finishes and could contribute to the rapid deterioration of the containment boundary, making it difficult to maintain appropriate pressure cascades. Animal Care. Ideally, the barrier facility would have dedicated loading areas. 0000005630 00000 n They should be located so that exhaust air does not enter the facility or other build-ings. Universal design is a planning approach which focuses on the diversity of building users during the facility design process. Sixty years later, SPF status has become a variable itself in biomedical research. 0000004206 00000 n The puppies are housed at the back. Animals are either born within or received into the barrier facility only after meeting rigorous testing to confirm they are free of the defined list of pathogens that are considered undesirable within the breeding colony. Close to raw materials, SPF also guarantees an efficient supply chain and back-up solutions for manufacturers around the world. Each facility has its own waste profile. 0000071173 00000 n In the case of poultry-breeding facilities that receive eggs to be hatched, a UV chamber may be needed for sterilizing the packaging of incoming eggs without harming the egg itself. Special consideration should be given to flooring and wall finishes, particularly in rooms that have open pens or where free-roaming poultry will be housed. Educational facilities are multi-purpose by nature. Her experience is focused primarily on large academic and government bio-containment research facilities with an emphasis on specialty cores: whole animal imaging, cellular imaging, insectary, aerobiology, etc. 0000010673 00000 n The critical ‘reproducibility’ requirement is met by breeding animal stock that provides a consistent, quantifiable baseline for experimentation. 0000003830 00000 n 0000010095 00000 n (SPF) Specific Pathogen Free Animal Breeding & Research Facility Complex UPM, Serdang Bio Safety Level 3 (BSL3) & Animal Bio Safety Level 3 (ABSL3) Laboratories … SPF regional teams have an acute understanding of local pet food market needs and challenges. The scope of activities may include research and production of genotypes stock for medical and bioresearch use elsewhere. x�b```c``��E� cc`a�X��$��3`� �u��K' 0000001855 00000 n laboratory animal facilities — characteristics, design and development, 2003. of air. The fumigation programme was started with methyl bromide treatment directed primarily against arthropods, followed by ammonia spray to kill coccidial oocysts and concluded by three formaldehyde treatments with fog and spray against … Germfree, Gnotobiotic, or SPF? The goal was to provide animals with selected microbiota compatible with sustained health. Additional procedural spaces may be required for work associated with some species such as poultry, for incubation or hatching. Traditional containment design prevents pathogens from leaving the containment envelope by using negative pressure cascades and sealed boundaries. Animal barrier facilities are designed and operated to provide pathogen free environments for the animals bred within. The design should consider how the animals will be removed, in what quantities they will be moved and where they will be taken. 0000006168 00000 n 0000070700 00000 n 0000011720 00000 n 0000005343 00000 n 0000005044 00000 n 0000015654 00000 n 0000003291 00000 n (4) Animal infection experiment in biosafety laboratory. Penetrations must be tightly sealed to meet room volume testing and facilitate decontamination of the suite. Sequences are arranged to provide sterilization of both personnel and materials inbound to the area. 0000059926 00000 n p. 16 3. 0000035807 00000 n 3{�,lv�>�i��I��6ue�^�)a�耀���P��� S�� ��"���zl2�D?�9��mH`8�8����A�]CV�o&.���>7�5�f�7E�͆ Animal Selection and Preoperative Preparation. Outer clothing and footwear is removed and stored, personnel then use the pass-through body shower before entering a clean change room where the sterilized PPE is donned before entering the barrier core. Copyright © 2021 All Rights Reserved. Preference should be given to biodegradable and eco-friendly animal … (1) IVC can be used for breeding production of SPF-class experimental animals. This change sequence typically is an access-controlled dirty change room, which is entered from the corridor. The design should consider both the physical requirements of the barrier space as well as the operational needs of this specialized function. Master Construction Specifications, Design Guideline Elements and other supplemental resources such as Interior Finishes Standards, Installation Details and HVAC Control Contract Document Requirements, are all combined under the heading of the Owner's Design Guidelines. This may include HEPA filtration of the supply air, but also should include directional airflow to support positive pressure cascade from clean to potentially contaminated spaces.2. Designing for Containment In barrier suites where multiple holding rooms are included, zone isolation of the separate holding rooms to permit individual decontamination of the spaces is advisable. This includes, and truly begins, with proving that animal models forming the basis of research are as homogenous as feasible from the outset, and this has driven demand for rigorous design of SPF barrier facilities. This may be human, animal, or plant material. 0000002818 00000 n This 13,000-ft 2 facility includes specific pathogen-free transgenic animal suites, 2 surgical rooms and adjacent treatment and prep areas, conventional animal rooms, and a separate wing housing wild-caught species. “We wanted animal shelters that invited people in and made them comfortable enough to create a relationship with a pet,” said Linda Gordon, a former liaison to the Bureau of Engineering for L.A. %PDF-1.4 %���� 97 0 obj <> endobj (3) The use of IVC in various short-term animal experiments is more in line with actual needs. %%EOF Alternative Design Manufacturing & Supply, Inc. https://www.laboratoryequipment.com/article/2010/06/biosecurity-laboratory-animal-facility, Website Designed and Maintained by The Belford Group, Guide for the Care and Use of Laboratory Animals, 8. 0000059714 00000 n 0000005007 00000 n Solutions for these common areas can be tailored to the specific laboratory objectives. Conversely, animals bred within open or exposed caging systems within a barrier facility do develop microflora and are not classified gnotobiotic due to their exposure to microorganisms within the room. Animal bedding makes up approximately 12% of our solid waste stream at the National Institutes of Health. Previously specified temperature and humidity ranges can be modified to meet special animal needs in circumstances in which all or most of the animal facility is designed exclusively for acclimated species with similar requirements (e.g., when animals are held in a sheltered or outdoor facility). (2) Suitable for breeding and conservation of small or precious clean grade and SPF laboratory animals. To meet animal needs, reduce animal stress and allow staff to care for animals safely and efficiently, housing should be double-compartment. Specific-pathogen-free (SPF) is a term used for laboratory animals that are guaranteed free of particular pathogens.Use of SPF animals ensures that specified diseases do not interfere with an experiment. The initial sanitization and sterilization of a newly built animal facility for the breeding and holding of specified pathogen free (SPF) rats and mice is described. Integral epoxy floor, wall, and ceiling coatings are recommended though monolithic, slip resistant surfaces. The Laws, Regulations, and Guidelines for Animal Research in China Mainland (China), Japan, and South Korea (Korea) will be discussed in this chapter. Large Animal Bio Safety Level 3 Agriculture Complex (BSL3 AG) Public Health BSL 3 Facilities. This multi-purpose concept requires designers to think strategically about how the facility meets diverse user needs and simultaneously serve a range of functions. 0000003679 00000 n 0000006466 00000 n The staff includes 5 full-time employees plus student labor. Animal Pi ki NPicking N C Research Facilities 2009 Tradeline Conference Series BARRIER FACILITIES N CtNew Cost-Eff ti S l ti f Effective Solutions from a Range of Options Concurrent Forum Session Concurrent Forum Session J“J” October 19, 2009 Lloyd E.L. Fisk, AIA LEED AP Reseaesea c ac es es grch Facilities Design 0000006767 00000 n The benefits of automated systems for watering and cagewash, and a robust database to capture a host of operational details—from sterilization runs to task scheduling to costing—have been clearly proven. For example, absence of respiratory pathogens such as influenza is desirable when investigating a drug's effect on lung function. In this episode, Lab Rat Chat hosts talk to AAALAC Senior Director Dr. Helen Diggs about AAALAC's mission and work, and why AAALAC has been "so critical to the continued evolution of animal care and use standards." Dr Jenny Kingham is a veterinarian, with 25 years experience in the management and design of laboratory animal facilities. endstream endobj 98 0 obj <>/Outlines 8 0 R/Metadata 27 0 R/PieceInfo<>>>/Pages 26 0 R/PageLayout/OneColumn/OCProperties<>/OCGs[99 0 R]>>/StructTreeRoot 29 0 R/Type/Catalog/Lang(�� E N - U S)/LastModified(D:20081125141459)/PageLabels 24 0 R>> endobj 99 0 obj <. If a range of species will be housed, design requirements regarding noise, vibration, temperature, humidity and lighting for all species under consideration must be met. All finishes must be resistant to chemical disinfectants and designed to withstand hot water hose-down procedures. If an animal watering system is provided, it should include reverse osmosis treatment to remove potentially infectious agents. Our experts design the most efficient breeding scheme to save on … Animals born via c-section and housed in closely monitored aseptic microisolator environments do not develop complex microflora and can be classified ‘germfree’ or ‘gnotobiotic,’ allowing the researcher to control exposure to relevant microorganisms relevant to their research. These perimeter spaces—change areas, showers, autoclaves and fumigation chambers—are designed as slightly positive to the corridor, with spaces becoming increasingly differentially pressure positive the further inbound into the barrier suite they are located. �I��bV0w�V�:^I08ڰAߍ9�u���5>3 A suitable breeding environment is important to have large litter sizes and shorten the timelines to produce mouse models. SPF animals are special stock of animals that are kept in specific pathogen free facilities under rigorous monitoring system, which are subjected to sensitive and accurate diagnostic methods. endstream endobj 147 0 obj <>/Size 97/Type/XRef>>stream Specific-pathogen free (SPF) animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. For mice and rats, SPF refers to animals that are free of most exogenous viruses and other pathogenic microorganisms.”1. The swine center is a specific-pathogen-free (SPF) facility. 0000100485 00000 n 0000059451 00000 n Where ABPs are classified as Category 3, we offer an environmentally friendly treatment – anaerobic digestion or biogas facility. Scientific need defines both the barrier requirements as well as the pathogen exclusion of any given colony, but the use of barrier facilities in breeding is generally based on the need to precisely control the health status of the research animals, provide genetically equivalent sample stock, optimize breeding and life span, and increase the repeatability and reproducibility for animal experiments. Depending on the breeding requirements, the barrier may be defined as the microisolator environment in which an animal is housed or as the entire suite. ���Cx����` ��g``�����4��8�8 ��W��a`��e�0 KC% Travel paths of materials, animals and personnel should be carefully planned to eliminate unnecessary exposure to contaminants and minimize travel distance to support functions such as loading docks. 0000070955 00000 n Animal Services, who recently retired. 0000064399 00000 n Facility Designation for Rodents RARC assigns a number designation to all facilities that house rodents. Wrapped food and bedding may be fumigated within a sealed chamber upon entry, while other non-perishable items may be autoclaved at the boundary. trailer David Lee-Parritz, in Surgical Research, 2001. 0000010417 00000 n 0000002390 00000 n Categories Explained: Category 1 ABPs include: Any domestic or wild animal infected or suspected as being infected with a disease transmittable to humans or animals is classified as Category 1 ABP. <<5064AD3DD37E6242ADACEA5E35086D96>]>> As a one-stop systems integrator for projects, we provide planning, consultancy & project management services in addition to engineering, internal fit-out solutions & preventative maintenance programmes that cater to all aspects of the laboratory & commercial facilities. 0000060175 00000 n 0000047554 00000 n Drinking water must be treated as a consumable and be sterilized. These recommendations intend for all animals to be housed individually (exceptions: mothers and offspring, bonded pairs, juveniles, purpose-designed group housing). The dirty side may require prep or de … startxref 0000008099 00000 n SPF:a is an award-winning Los Angeles architecture firm specializing in the design of cultural buildings, civic works, residential developments, and creative office space. At all perimeter entries for both personnel and materials, interlocked, access-controlled doors should be provided. Some of the key facilities and centers are described below. She is Director of Animal Facilities at the Garvan Institute of Medical Research inSydney, Australia and is CEO of the Australian BioResources facility. Unless the facility has dedicated processes involving a single species, animal holding rooms should be designed to accommodate a range of species to permit future changes in operations. Through her design, Alomar is, essentially, marketing the animals. The solutions they design are perfectly adapted to meet the local expectations. These animals “may be referred to as specific pathogen-free (SPF) to indicate that the colony from which they originated tested negative for certain pathogens and perhaps other adventitious agents that may interfere with research without causing disease. Similarly, the entry and exit sequences into a barrier facility are designed to prevent contaminants entering from corridors. ITS Labworks provides design & engineering solutions that cater to the laboratory, medical & commercial projects. 0000004595 00000 n 0000087548 00000 n 0000001336 00000 n The housing recommended will meet most animals’ needs for up to about a two-week shelter … Rainey Hufstetler is a registered architect with 15 years of high containment design expertise in highly technical laboratory and animal facilities. Animal barrier facilities are designed and operated to provide pathogen free environments for the animals bred within. Violations will be recorded and reported to the IACUC through the IACUC Coordinator, IACUC Chair, or LAR personnel. Biocytogen’s AAALAC accredited SPF animal facilities provide optimal breeding environments. Photo courtesy of HERA laboratory planners. Enhanced mechanical isolation of the positive pressure environment is critical when a barrier facility is incorporated into a greater research facility, particularly in areas where a physical isolation via buffer is not planned. The animal holding rooms, where colonies are born and reared, are the most positive to the surrounding support spaces which maximizes isolation of the animals and ensures the desired health status. x�bbg`b``�` �� � solutions for animal transport, anesthesia delivery, animal preparation and monitoring, and data management will be common among most facilities. 0000004735 00000 n 0000004873 00000 n Specific Pathogen Free (SPF) Level 1 Facilities Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain Specific-pathogen-free rodents should be used for all surgical procedures to reduce morbidity and mortality from chronic respiratory disease. 0000006689 00000 n The walls and ceilings within a barrier facility must withstand the pressure differentials within the suite, as well as prevent vermin transmission. Animal transport Facility barriers SPF solutions Multimodal transport Animal care Anesthesia (injection/gas) Lab Rat Chat talks to AAALAC's Dr. Diggs. 0000063959 00000 n 0000100748 00000 n A cornerstone of successful shelter design is determining the right size and type of animal housing. Image: The Joseph E. Walther Hall (Research III Building) at Indiana University School of Medicine. These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. Special Considerations for Animal Rooms Interior spaces within a breeding suite may include multiple holding rooms for animal rearing, separate procedure space, sterile material storage areas and work rooms for staging, logging and support equipment. 0000064612 00000 n DOI: 10.15406/mojt.2018.04.00100 Replacement: methods which avoid or replace the use of animals in Research. 0000004462 00000 n xref While there are significant differences in how these have been developed and implemented in each country, they are based on basic ethical principle… SPF facilities use similar boundary strategies, with a positive pressure cascade to prevent entry of outside air and pathogens to maintain laboratory breeding colonies free of diseases that would conflict with or inhibit research results. Not only does this type of separation lessen the strain on the mechanical system, but it also lessens the transmission probability between one side of the wall and the other via improperly sealed penetrations that permit possibly contaminated air, water or vermin from adjacent spaces to infiltrate the barrier facility. As scientific rigor continues to evolve, it has become increasingly important to document any external factors that might have an impact on the final research data. High containment design capitalizes on the physical isolation provided by a box-in-a-box design by providing a physical separation of the containment block inside a zone that is not bound by exterior wind and temperature conditions. NRC, 2011): security features, such as card-key systems, electronic surveillance, and alarms to ensure access control; animal housing areas, possibly including special barrier facilities for housing of Specific Change sequences should also provide either an air, or preferably, a water shower to ensure that personnel are thoroughly clean prior to donning sterilized PPE and entering the suite. 0000064191 00000 n Ensuring optimal design and operations strategies, in conjunction with strong biosafety practices, are keys to a successful breeding program and enable scientific discovery. Where containment boundary equipment such as an autoclave or pass box are provided, bioseals shall also be included. To support the rigorous breeding and health testing protocols of these animal colonies, barrier and SPF facilities are designed as containment facilities, making both isolation and sealability important factors in the design. In some facilities, it may be appropriate to maintain dedicated “clean” PPE within the facility at the clean change side to reduce sterilization and laundering of PPE. If this is not feasible, the incoming air and/or exhaust must be treated appropriately. 0000001685 00000 n The Department of Laboratory Animal Resources (LAR) maintains a specific pathogen free (SPF) animal area for SPF mice. Change sequences should be incorporated at the suite entry to permit personnel to change into complete SPF-dedicated personal protective equipment (PPE) including sterilized footwear, scrubs or gowning, eyewear, and any additional safety covering necessary for working with animals. Similarly, all incoming materials including food and bedding must be sterilized at the barrier boundary. Some of the earliest decisions to be made in the planning process are circulation issues, both outside and inside an animal facility. 148 0 obj <>stream As such, animal holding rooms, as well as fumigation entry points to the suite, shall be designed for worst-case scenario caging or isolator size requirements and should include turn-radii and doors sized to accommodate larger caging. Conservation of small or precious clean grade and SPF laboratory animals Lee-Parritz, in what they... This may be fumigated within a sealed chamber upon entry, while other non-perishable items may required! This is not feasible, the incoming air and/or exhaust must be treated as a consumable and sterilized... When planning functional adjacencies a barrier facility are designed to withstand hot water hose-down.. Discovery is dependent on the ability to formulate a process, reproduce tests, and and. 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